{"id":498,"date":"2026-01-22T10:03:26","date_gmt":"2026-01-22T10:03:26","guid":{"rendered":"https:\/\/project.eortc.org\/recist\/?p=498"},"modified":"2026-01-22T13:59:36","modified_gmt":"2026-01-22T13:59:36","slug":"liquid-biopsy-to-imaging","status":"publish","type":"post","link":"https:\/\/project.eortc.org\/recist\/liquid-biopsy-to-imaging\/","title":{"rendered":"Liquid biopsy to imaging"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-margin-top:4%;--awb-margin-bottom:4%;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1248px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-title title fusion-title-1 fusion-sep-none fusion-title-text fusion-title-size-two\" style=\"--awb-margin-top-small:10px;--awb-margin-right-small:0px;--awb-margin-bottom-small:10px;--awb-margin-left-small:0px;\"><h2 class=\"fusion-title-heading title-heading-left\" style=\"margin:0;\">Is it time to add liquid biopsy to imaging based response assessment?<\/h2><\/div><div class=\"fusion-text fusion-text-1\"><p>Early identification of metastatic cancer response is critical for optimizing therapy and accelerating drug development, yet RECIST imaging-based criteria typically require 6\u201312 weeks and measurable disease. Emerging evidence shows that on-treatment changes in circulating tumor DNA (ctDNA) could help detect response or resistance earlier. To address this, the RECIST Working Group has reviewed current data and outlined priorities for integrating ctDNA into response evaluation, including standardized datasets, timing, assay thresholds, and regulatory considerations. Clinically meaningful ctDNA changes vary by cancer type and therapy, requiring rigorous validation before pan-cancer adoption. Despite these challenges, ctDNA offers a minimally invasive, promising complement to RECIST and a potential early endpoint for modern trials. Therefore, the RECIST Working Group is evaluating the available and required evidence to update RECIST.<\/p>\n<\/div><div class=\"fusion-title title fusion-title-2 fusion-sep-none fusion-title-text fusion-title-size-two\" style=\"--awb-margin-top-small:10px;--awb-margin-right-small:0px;--awb-margin-bottom-small:10px;--awb-margin-left-small:0px;\"><h2 class=\"fusion-title-heading title-heading-left\" style=\"margin:0;\">Project leaders:<\/h2><\/div><div class=\"fusion-text fusion-text-2\"><ul>\n<li>Elena Garralda, VHIO, SE<\/li>\n<\/ul>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":499,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-498","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ongoing"],"_links":{"self":[{"href":"https:\/\/project.eortc.org\/recist\/wp-json\/wp\/v2\/posts\/498","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/project.eortc.org\/recist\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/project.eortc.org\/recist\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/project.eortc.org\/recist\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/project.eortc.org\/recist\/wp-json\/wp\/v2\/comments?post=498"}],"version-history":[{"count":2,"href":"https:\/\/project.eortc.org\/recist\/wp-json\/wp\/v2\/posts\/498\/revisions"}],"predecessor-version":[{"id":522,"href":"https:\/\/project.eortc.org\/recist\/wp-json\/wp\/v2\/posts\/498\/revisions\/522"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/project.eortc.org\/recist\/wp-json\/wp\/v2\/media\/499"}],"wp:attachment":[{"href":"https:\/\/project.eortc.org\/recist\/wp-json\/wp\/v2\/media?parent=498"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/project.eortc.org\/recist\/wp-json\/wp\/v2\/categories?post=498"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/project.eortc.org\/recist\/wp-json\/wp\/v2\/tags?post=498"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}