Peer reviewed publications

R. Sinkus, B.E. Van Beers, V. Vilgrain, N. DeSouza, J.C. WatertonApparent diffusion coefficient from magnetic resonance imaging as a biomarker in oncology drug developmentEuropean Journal of Cancer2012484425-431
D. Soloviev, D. Lewis, D. Honess, E. Aboagye[18F]FLT: An imaging biomarker of tumour proliferation for assessment of tumour response to treatment.European Journal of Cancer2012484416-424
Q. Nguyen, A. Challapalli , G. Smith , R. Fortt, E.O. AboagyeImaging apoptosis with positron emission tomography: ‘Bench to bedside’ development of the caspase-3/7 specific radiotracer [18F]ICMT-11.European Journal of Cancer2012484432-440
J.C. Waterton, L. PylkkaanenQualification of imaging biomarkers for oncology drug development.European Journal of Cancer2012484409-415
P. Lambin, E. Rios-Velazquez, R. Leijenaar, S. Carvalho, R. GPM van Stiphout, P. Granton, C. ML Zegers, R. Gillies, R. Boellard, A. Dekker, H. JWL AertsRadiomics: Extracting more information from medical images using advanced feature analysis.European Journal of Cancer2012484441-446
M.-C. Asselin, J. PB O’Connor, R. Boellaard, N. A Thacker, A. JacksonQuantifying heterogeneity in human tumours using MRI and PET.European Journal of Cancer2012484447-455
P. Lambin, E. Roelofs, B. Reymen, E. Rios Velazquez, J. Buijsen, K. Zegers, S. Carvalho, R. Leijenaar, G. Nalbantov, C. Oberije, M. Scott Marshall, F. Hoebers, E.G.C. Troost, R.G.P.M. van Stiphout, W. van Elmpt, T. van der Weijden, L. Boersma, V. Valentini, A. Dekker‘Rapid Learning health care in oncology’ – An approach towards decision support systems enabling customised radiotherapy’.Radiotherapy and Oncology2013
V. Frings, A.A. van der Veldt, R. Boellaard, G.J. Herder, E. Giovannetti, R. Honeywell, G.J. Peters, E. Thunnissen, O.S. Hoekstra, E.F. SmitPemetrexed induced thymidylate synthase inhibition in non-small cell lung cancer patients: a pilot study with 3'-deoxy-3'-[¹⁸F]fluorothymidine positron emission tomography.PLoS One201385e63705
H. Ragheb, N.A. Thacker, D.M. Morris, N.H.M. Hogg, A. JacksonIce-Water Phantom Localisation for Diffusion CalibrationMedical Image Understanding and Analysis (MIUA), Swansea University, Swansea, UK2012179-184
Starmans M.H., Pintilie M., John T., Der S.D., Shepherd F.A., Jurisica I., Lambin P., Tsao M.S., Boutros P.C.Exploiting the noise: improving biomarkers with ensembles of data analysis methodologies.Genome Medicine201241184
Rios Velazquez E., Aerts H.J., Gu Y., Goldgof D.B., De Ruysscher D., Dekker A., Korn R., Gillies R.J., Lambin P.A semiautomatic CT-based ensemble segmentation of lung tumors: Comparison with oncologists' delineations and with the surgical specimen.Radiotherapy & Oncology20121052167-173
van der Heide U.A., Houweling A.C., Groenendaal G., Beets-Tan R.G., Lambin P.Functional MRI for radiotherapy dose painting.Magnetic Resonance Imaging20123091216-1223
Lambin P., van Stiphout R.G., Starmans M.H., Rios-Velazquez E., Nalbantov G., Aerts H.J., Roelofs E., van Elmpt W., Boutros P.C., Granone P., Valentini V., Begg A.C., De Ruysscher D., Dekker A.Predicting outcomes in radiation oncology-multifactorial decision support systems.Nature Reviews Clinical Oncology201310127-40
Carvalho S., Leijenaar R.T., Velazquez E.R., Oberije C., Parmar C., van Elmpt W., Reymen B., Troost E.G., Oellers M., Dekker A., Gillies R., Aerts H.J., Lambin P.Prognostic value of metabolic metrics extracted from baseline positron emission tomography images in non-small cell lung cancer.Acta Oncologica20135271398-1404
E. Roelofs, L. Persoon, S. Nijsten, W. Wiessler, A. Dekker, P. LambinBenefits of a clinical data warehouse with data mining tools to collect data for a radiotherapy trial.Radiotherapy & Oncology20131081174-179
Leijenaar R.T., Carvalho S., Velazquez E.R., van Elmpt W.J., Parmar C., Hoekstra O.S., Hoekstra C.J., Boellaard R., Dekker A.L., Gillies R.J., Aerts H.J., Lambin P.Stability of FDG-PET Radiomics features: An integrated analysis of test-retest and inter-observer variabilityActa Oncologica20135271391-1397
Timothy H. Witney, Robin R. Fortt, Eric O. AboagyePreclinical Assessment of Carboplatin Treatment Efficacy in Lung Cancer by 18F-ICMT-11-Positron Emission TomographyPLoS One201493e91694
Hugo J. W. L. Aerts, Emmanuel Rios Velazquez, Ralph T. H. Leijenaar, Chintan Parmar, Patrick Grossmann, Sara Cavalho, Johan Bussink, René Monshouwer, Benjamin Haibe-Kains, Derek Rietveld, Frank Hoebers, Michelle M. Rietbergen, C. René Leemans, Andre Dekker, John Quackenbush, Robert J. Gillies, and Philippe LambinDecoding tumour phenotype by noninvasive imaging using a quantitative radiomics approachNature Communications201454006
Virginie Frings, Maqsood Yaqub, Lieke L. Hoyng, Sandeep S.V. Golla, Albert D. Windhorst, Robert C. Schuit, Adriaan A. Lammertsma,
Otto S. Hoekstra, Egbert F. Smit, Ronald Boellaard
Assessment of Simplified Methods to Measure 18F-FLT Uptake Changes in EGFR-Mutated Non–Small Cell Lung Cancer Patients Undergoing EGFR Tyrosine Kinase Inhibitor TreatmentThe Journal of Nuclear Medicine20145591417-1423
Sonja Schelhaas,
Lydia Wachsmuth, Thomas Viel, Davina J. Honess, Kathrin Heinzmann, Donna-Michelle Smith, Sven Hermann, Stefan Wagner, Michael T. Kuhlmann, Carsten Müller-Tidow, Klaus Kopka,
Otmar Schober, Michael Schäfers,
Richard Schneider, Eric O. Aboagye,
John Griffiths, Cornelius Faber, Andreas H. Jacobs
Variability of Proliferation and Diffusion in Different Lung Cancer Models as Measured by 3′-Deoxy-3′-18F-Fluorothymidine PET and Diffusion-Weighted MR ImagingThe Journal of Nuclear Medicine2014556983-988
Emmanuel Rios Velazquez, Chintan Parmar, Mohammed Jermoumi1,3, Raymond H. Mak,
Angela van Baardwijk, Fiona M. Fennessy, John H. Lewis, Dirk De Ruysscher, Ron Kikinis,
Philippe Lambin, Hugo J. W. L. Aerts
Volumetric CT-based segmentation of
NSCLC using 3D-Slicer
Scientific Reports201333529
Bernardin L, Douglas NH, Collins DJ, Giles SL, O'Flynn EA, Orton M, deSouza NM.Diffusion-weighted magnetic resonance imaging for assessment of lung lesions: repeatability of the apparent diffusion coefficient measurementEuropean Radiology2014242502-511
Livia Bernardin, Elizabeth A.M. O’Flynn, Nandita M. deSouzaFunctional imaging biomarkers for assessing response to treatment in liver and lung metastasesCancer Imaging2013134482-494
Virginie Frings, Adrianus J. de Langen, Maqsood Yaqub, Robert C. Schuit, Astrid A. M. van der Veldt, Otto S. Hoekstra, Egbert F. Smit, Ronald BoellaardMethodological Considerations in Quantificationof 3'-Deoxy-3'-[18F]Fluorothymidine Uptake Measured with Positron Emission Tomography in Patients with Non-Small Cell Lung CancerMolecular Imaging and Biology2014161136-145
Natalie S Fox, Maud HW Starmans, Syed Haider, Philippe Lambin, Paul C BoutrosEnsemble analyses improve signatures of tumour
hypoxia and reveal inter-platform differences
BMC Bioinformatics201415170
Lieke L Hoyng, Virginie Frings, Otto S Hoekstra, Laura M Kenny, Eric O Aboagye, and Ronald BoellaardMetabolically active tumour volume segmentation from dynamic [18F]FLT PET studies in non-small cell lung cancerEJNMMI Research2015526
Winfield JM, Papoutsaki MV, Ragheb H, Morris DM, Heerschap A, Ter Voert EG, Kuijer JP, Pieters IC, Douglas NH, Orton M, de Souza NM; QuIC-ConCePT ConsortiumDevelopment of a diffusion-weighted MRI protocol for multi-centre abdominal imaging and evaluation of the effects of fasting on measurement of apparent diffusion coefficients (ADCs) in healthy liverThe British Journal of Radiology2015881049
Doblas S, Almeida GS, Blé FX3, Garteiser P, Hoff BA, McIntyre DJ, Wachsmuth L, Chenevert TL, Faber C, Griffiths JR, Jacobs AH, Morris DM,O'Connor JP, Robinson SP, Van Beers BE, Waterton JCApparent diffusion coefficient is highly reproducible on preclinical imaging systems: Evidence from a seven-center multivendor studyJournal of Magnetic Resonance Imaging2015
Bollineni VR, Kramer G, Liu Y, Melidis C, deSouza NMA literature review of the association between diffusion-weighted MRI derived apparent diffusion coefficient and tumour aggressiveness in pelvic cancerCancer Treatment Reviews2015416496–502
Guyader JM, Bernardin L, Douglas NH, Poot DH, Niessen WJ, Klein SInfluence of image registration on apparent diffusion coefficient images computed from free-breathing diffusion MRI of the abdomenJournal of Magnetic Resonance Imaging2014422315-330
Skripcak T, Belka C, Bosch W, Brink C, Brunner T, Budach V, Büttner D, Debus J, Dekker A, Grau C, Gulliford S, Hurkmans C, Just U, Krause M, Lambin P, Langendijk JA, Lewensohn R, Lühr A, Maingon P, Masucci M, Niyazi M, Poortmans P, Simon M, Schmidberger H, Spezi E,Stuschke M, Valentini V, Verheij M, Whitfield G, Zackrisson B, Zips D, Baumann MCreating a data exchange strategy for radiotherapy research: towards federated databases and anonymised public datasetsRadiotherapy and Oncology20141133303-309
van Stiphout RG, Valentini V, Buijsen J, Lammering G, Meldolesi E, van Soest J, Leccisotti L, Giordano A, Gambacorta MA, Dekker A, Lambin PNomogram predicting response after chemoradiotherapy in rectal cancer using sequential PETCT imaging: a multicentric prospective study with external validationRadiotherapy and Oncology20141132215-222
Frings V, van Velden FH, Velasquez LM, Hayes W, van de Ven PM, Hoekstra OS, Boellaard RRepeatability of metabolically active tumor volume measurements with FDG PET/CT in advanced gastrointestinal malignancies: a multicenter studyRadiology20142732539-548
Coroller TP, Grossmann P, Hou Y, Rios Velazquez E, Leijenaar RT, Hermann G, Lambin P, Haibe-Kains B, Mak RH, Aerts HJCT-based radiomic signature predicts distant metastasis in lung adenocarcinomaRadiotherapy and Oncology20151143345-350
Parmar C, Rios Velazquez E, Leijenaar R, Jermoumi M, Carvalho S, Mak RH, Mitra S, Shankar BU, Kikinis R, Haibe-Kains B, Lambin P, Aerts HJRobust Radiomics feature quantification using semiautomatic volumetric segmentationPlosOne201597102-107
Grove O, Berglund AE, Schabath MB, Aerts HJ, Dekker A5, Wang H, Velazquez ER, Lambin P, Gu Y, Balagurunathan Y, Eikman E, Gatenby RA,Eschrich S, Gillies RJQuantitative computed tomographic descriptors associate tumor shape complexity and intratumor heterogeneity with prognosis in lung adenocarcinomaPlosOne2015103
Toma-Dasu I, Uhrdin J, Lazzeroni M, Carvalho S, van Elmpt W, Lambin P, Dasu AEvaluating tumor response of non-small cell lung cancer patients with ¹⁸F-fludeoxyglucose positron emission tomography: potential for treatment individualizationInternational Journal of Radiation Oncology2015912376-384
Ragheb H, Thacker NA, Guyader JM, Klein S, deSouza NM, Jackson AThe accuracy of ADC measurements in liver is improved by a tailored and computationally efficient local-rigid registration algorithmPlosOne2015107
Panth KM, Leijenaar RT, Carvalho S, Lieuwes NG, Yaromina A, Dubois L, Lambin P.Is there a causal relationship between genetic changes and radiomics-based image features? An in vivo preclinical experiment with doxycycline inducible GADD34 tumor cells. doi: 10.1016/j.radonc.2015.06.013Radiotherapy and Oncology20151163461-6
Lambin P, Zindler J, Vanneste B, van de Voorde L, Jacobs M, Eekers D, Peerlings J, Reymen B, Larue RT, Deist TM, de Jong EE, Even AJ, Berlanga AJ, Roelofs E, Cheng Q, Carvalho S, Leijenaar RT, Zegers CM, van Limbergen E, Berbee M, van Elmpt W, Oberije C, Houben R, Dekker A, Boersma L, Verhaegen F, Bosmans G, Hoebers F, Smits K, Walsh S.Modern clinical research: How rapid learning health care and cohort multiple randomised clinical trials complement traditional evidence based medicine. doi: 10.3109/0284186X.2015.1062136Acta Oncologica20155491289-300
Liu Y, deSouza NM, Shankar LK, Kauczor HU, Trattnig S, Collette S, Chiti A.A risk management approach for imaging biomarker-driven clinical trials in oncology. doi: 10.1016/S1470-2045(15)00164-3Lancet Oncology
Kranthi Marella Panth, Twan van den Beucken, Rianne Biemans, Natasja G. Lieuwes, Marcel Weber, Mario Losen, Ala Yaromina, Ludwig J. Dubois & Philippe LambinIn vivo optical imaging of MMP2 immuno protein antibody: tumor uptake is associated with MMP2 activity doi:10.1038/srep22198Scientific Reports2016622198
Bollineni VR, Kramer GM, Jansma EP, Liu Y, Oyen WJ.A systematic review on [(18)F]FLT-PET uptake as a measure of treatment response in cancer patients. doi: 10.1016/j.ejca.2015.11.018European Journal of Cancer20165581-97
Catharina M. L. Zegers & Frank J. P. Hoebers & Wouter van Elmpt1 & Judith A. Bons2 & Michel C. Öllers & Esther G. C. Troost & Daniëlle Eekers & Leo Balmaekers & Marlies Arts-Pechtold & Felix M. Mottaghy & Philippe LambinEvaluation of tumour hypoxia during radiotherapy using [18F] HX4 PET imaging and blood biomarkers in patients with head and neck cancer DOI 10.1007/s00259-016-3429-yEur J Nucl Med Mol Imaging201643122139-2146
W. Huizinga, D.H.J. Poot, J.-M. Guyader, R. Klaassen, B.F. Coolen, M. van Kranenburge, R.J.M. van Geunse, A. Uitterdijk, M. Polfliet, J. Vandemeulebroucke, A. Leemans, W.J. Niessen, b, S. KleinPCA-based groupwise image registration for quantitative MRI
Med Image Anal20162965-78
Weller A, O'Brien ME, Ahmed M, Popat S, Bhosle J, McDonald F, Yap TA, Du Y, Vlahos I, deSouza NMMechanism and non-mechanism based imaging biomarkers for assessing biological response to treatment in non-small cell lung cancer.
doi: 10.1016/j.ejca.2016.02.017
Eur J Cancer20165965-78
Jerome NP, Papoutsaki MV, Orton MR, Parkes HG, Winfield JM, Boss MA, Leach MO, deSouza NM, Collins DJ.Development of a temperature-controlled phantom for magnetic resonance quality assurance of diffusion, dynamic, and relaxometry measurements.
doi: 10.1118/1.4948997
Med Phys20164362998
Sara Rapic, Christel Vangestel, Jeroen Verhaeghe, David Thomae, Patrick Pauwels, Tim Van den Wyngaert, Steven Staelens, Sigrid Stroobants
Evaluation of [18F]Fluorothymidine as a Biomarker for Early Therapy Response in a Mouse Model of Colorectal Cancer
DOI: 10.1007/s11307-016-0974-5
Mol Imaging Biol2016
Sonja Schelhaas, Kathrin Heinzmann, Vikram R. Bollineni, Gerbrand M. Kramer, Yan Liu, John C. Waterton, Eric O. Aboagye, Anthony F. Shields, Dmitry Soloviev, Andreas H. JacobsPreclinical Applications of 3’-Deoxy-3’-[ 18F] Fluorothymidine in Oncology – A Systematic Review
doi: 10.7150/thno.16676
James P. B. O'Connor, Eric O. Aboagye, Judith E. Adams, Hugo J. W. L. Aerts, Sally F. Barrington, Ambros J. Beer, Ronald Boellaard, Sarah E. Bohndiek, Michael Brady, Gina Brown, David L. Buckley, Thomas L. Chenevert, Laurence P. Clarke, Sandra Collette, Gary J. Cook, Nandita M. deSouza, John C. Dickson, Caroline Dive, Jeffrey L. Evelhoch, Corinne Faivre-Finn, Ferdia A. Gallagher, Fiona J. Gilbert, Robert J. Gillies, Vicky Goh, John R. Griffiths, Ashley M. Groves, Steve Halligan, Adrian L. Harris, David J. Hawkes, Otto S. Hoekstra, Erich P. Huang, Brian F. Hutton, Edward F. Jackson, Gordon C. Jayson, Andrew Jones, Dow-Mu Koh, Denis Lacombe, Philippe Lambin, Nathalie Lassau, Martin O. Leach, Ting-Yim Lee, Edward L. Leen, Jason S. Lewis, Yan Liu, Mark F. Lythgoe, Prakash Manoharan, Ross J. Maxwell, Kenneth A. Miles, Bruno Morgan, Steve Morris, Tony Ng, Anwar R. Padhani, Geoff J. M. Parker, Mike Partridge, Arvind P. Pathak, Andrew C. Peet, Shonit Punwani, Andrew R. Reynolds, Simon P. Robinson, Lalitha K. Shankar, Ricky A. Sharma, Dmitry Soloviev, Sigrid Stroobants, Daniel C. Sullivan, Stuart A. Taylor, Paul S. Tofts, Gillian M. Tozer, Marcel van Herk, Simon Walker-Samuel, James Wason, Kaye J. Williams, Paul Workman, Thomas E. Yankeelov, Kevin M. Brindle, Lisa M. McShane, Alan Jackson & John C. WatertonImaging biomarker roadmap for cancer studies
Nat Rev Clin Oncol2016

IMI oncology projects